How to Optimise Final Filling in Bioprocess Webinar - Thursday, June 24th. Register Now >
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Get your single-use bioprocess workflows up and running quickly. Let us customize your assemblies or select from our wide-range of products to build your own. Choose Masterflex Single-Use Custom Disposable Sterile Assemblies and eliminate assembling, sterilizing, and validating with just one call to us. Or, select every component to build your own assemblies. Either way, we offer the widest selection of trusted brands in the bioprocess market for tubing, fittings, gaskets, sanitary fittings and clamps, and more. Too much to choose from? Consult with our technical experts to help you get exactly what you need, so you can start reaping the many benefits of single-use systems: reduced cross-contamination risks, lower capital investment, no more cleaning and sterilizing, reduced turnaround times, scale an operation up or down with limited additional investment, and so much more.
Affinity and ion-exchange chromatography are used to remove metals and reaction by-products along with additional methods of filtration. Recently, single-use tube component assemblies have become more prevalent in this workflow as higher throughputs and versatility on the process floor are demanded. The isolated fluid flow path of peristaltic pumps, such as Masterflex® pumps, is critical to this workflow. These pumps mitigate the potential for contamination and reduce the required material validation.
Typical harvest methods include Tangential Flow Filtration (TFF) or centrifugation as a means of concentrating the target compound. In either of these methods, quality and purity are paramount. Wetted materials (any material touching the fluid) must be validated USP Class VI and sterilized. Peristaltic pumps remain accurate at higher pressures, making them ideal for filtration centric workflows.
Industrial fermentation involves a sample a tank of controlled pH, aeration, agitation, temperature. It requires more preliminary steps than other bioprocess workflows. Common microorganisms used in this process are Chinese hamster ovary cells (CHO), yeast, fungi, and bacteria. Masterflex® peristaltic pumps are useful in this workflow and are recommended over diaphragm pumps. Peristaltic pumps provide accurate dosing capabilities and, unlike diaphragm pumps, have an isolated and unconvoluted fluid path. This makes maintenance easy and ensures no product gets stuck in a crevice.
|Peristaltic Pump Tubing||Quick-Disconnect Fittings||Carboys|
|Transfer Tubing||Gaskets||Barbed Fittings|
|Luer Fittings||Microbore and Autoanalysis Tubing||Sanitary Fittings and Clamps|